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  • ‘The Second Brain’ The Gut Microbiome’s Effect on Your Mental Health

    ‘The Second Brain’ The Gut Microbiome’s Effect on Your Mental Health

    By Gianna Lee

    ~ 4 minutes


    Every year, in the United States, millions are diagnosed with schizophrenia, autism, and depression . These disabilities severely hinder people’s way of living, therefore, it is crucial for us to find ways to prevent individuals from suffering. In the past few years, research has shown that the gut has a significant connection with your brain.

    The ENS

    The ENS (enteric nervous system) is what some researchers call your “second brain.” It is composed of two layers that have hundreds of millions of nerve cells that dictate your mood shifts. Located in the gut, this system efficiently communicates with the central nervous system, connecting your mind and body.

    The ENS sends signals to your brain via the gut-brain axis. For example, when the gut signals hunger, the brain sends out a stressor leading to your blood sugar dropping, which makes you frustrated or irritated. This shows that the brain and gut are in constant communication, which can be linked to mental illness.  With this logic, we can understand that while microorganisms within the gut can prevent mental illness, others can cause them.

    In cases of Schizophrenia, clinical research has shown similarities within the gut between patients; 8 cases of Schizophrenia found that their gut contained similar gut microbiota such as: Lactobacillus, Enterococcus, and Bifidobacterium. Scientists then prescribed probiotics to these patients which reduced inflammation and contributed to a better state and overall mood.

    The Mind and Gut’s Relationship

    While research is still being developed regarding the link between the two, findings are piling up in order to help us understand the relationship between the gut and mind.

    In order to maintain a healthy gut and mindset, there are a few ways to keep yourself healthy. You are what you eat. Your diet is a major factor for a healthy gut, so nourishing your gut with a diverse and balanced diet can feed bacteria, allowing for an improved mood! Some healthy nutrition options include probiotics such as: kimchi, kefir, and other fermented items, as well as  prebiotics like green vegetables, legumes, whole grains, and nuts.

    Additionally, ways to completely treat mental illness are still being discovered. A process called “Faecal microbiota transplant” has recently been found to be a possible cure. The process allows  donors with healthy guts to donate stool to patients suffering from infected colons. This process is usually used to treat infection, however, studies were done that found out a few cases of clinical depression were cured through this process. 

    To sum it up, the gut microbiome may not seem like much, however it does play a significant role in mental health. The link between the two is still being studied to this day, with new findings revealing that treatments may cure existing mental illness. As of now, the current best way to maintain a healthy mental state is to ensure a healthy diet. Hopefully, one day we will be able to cure mental illness through these ground breaking discoveries, and when that happens, I will be here to report it!


    References

    GBD 2019 Mental Disorders Collaborators. (2022). Global, regional, and national burden of 12 mental disorders in 204 countries and territories, 1990–2019: A systematic analysis for the Global Burden of Disease Study 2019. The Lancet Psychiatry, 9(2), 137–150. https://doi.org/10.1016/s2215-0366(21)00395-3
    Health, N. (2025). The gut-mental health connection: How to improve both for overall well-being. Nuvance Health. https://www.nuvancehealth.org/health-tips-and-news/the-gut-mental-health-connection
    Johns Hopkins Medicine. (2019). The brain-gut Connection. John Hopkins Medicine. https://www.hopkinsmedicine.org/health/wellness-and-prevention/the-brain-gut-connection
    Li, Z., Tao, X., Wang, D., Pu, J., Liu, Y., Gui, S., Zhong, X., Yang, D., Zhou, H., Tao, W., Chen, W., Chen, X., Chen, Y., Chen, X., & Xie, P. (2024). Alterations of the gut microbiota in patients with schizophrenia. Frontiers in Psychiatry, 15, 1366311. https://doi.org/10.3389/fpsyt.2024.1366311
    Morrow, R. (2021, November 17). 9 Soulicious Soup Recipes. Foodmatters.com; Food Matters. https://www.foodmatters.com/recipe/9-soulicious-soup-recipes